dosage
100-300mg per dose
when
how it helps
Potent metabolic antioxidant that crosses the blood-brain barrier. Directly scavenges reactive oxygen species (ROS) in mitochondria, preventing oxidative damage to serotonin neurons.
source: Pubmed 10619665
dosage
500-1000mg
when
how it helps
Supports mitochondrial energy production and membrane repair. Prevents mitochondrial DNA deletion caused by MDMA-induced oxidative stress.
source: Pubmed 19015003
dosage
500-1000mg
when
how it helps
Water-soluble antioxidant that neutralizes free radicals in the cytosol. Works synergistically with ALA and Vitamin E for broad-spectrum protection.
source: Pubmed 11170222
dosage
600-1200mg daily
when
how it helps
Precursor to glutathione, the body's "master" endogenous antioxidant. MDMA metabolism depletes glutathione reserves; NAC replenishes them.
source: Pubmed 23975535
dosage
200-400mg
when
how it helps
Calcium channel blocker and neuromuscular relaxant. Reduces acetylcholine release at neuromuscular junction, dampening muscle hyperactivity (jaw clenching).
source: Multiple sources on bruxism management
dosage
250-500ml/hour of isotonic fluid
when
how it helps
Prevents hyponatremia (water intoxication) which can occur from MDMA-induced ADH secretion combined with excessive water intake.
source: Clinical case reports, harm reduction consensus
dosage
0.5-3mg before bed
when
how it helps
Aids sleep recovery which is essential for neurological repair. Also has antioxidant properties that may support recovery.
source: General sleep medicine
dosage
400mg
when
how it helps
Catechins in green tea have strong antioxidant properties. May also inhibit COMT enzyme, affecting metabolism.
source: Harm reduction community protocols